Background The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age. Methods We used individual-level data (n=66 951, 49.1% men, age range 40–98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF. Results AF incidence increased from 0.9 per 1000 person-years at baseline age 40–49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p<0.05). Between 30% and 40% of the AF risk could be attributed to BMI, hypertension and a history of stroke or MI. New-onset AF was associated with a twofold increase in risk of stroke and death at ages≥70 years (p≤0.001). Conclusion In this large European cohort aged 40 years and above, risk of AF was largely attributed to BMI, high alcohol consumption and a history MI or stroke from middle age. Thus, preventive measures for AF should target risk factors such as obesity and hypertension from early age and continue throughout life. The data are not available in a public repository. Access to the data is restricted by the ethical approvals and the legislation of the European Union and the countries of each MORGAM study. Approval by the Principal Investigator of each cohort study and the MORGAM/BiomarCaRE Steering Group will be required for release of the data. The MORGAM Manual at gives more information on access to the data.

中文翻译：

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特定年龄的心房颤动发病率、可归因的危险因素以及中风和死亡的风险：来自 MORGAM 联盟的结果

背景 主要目的是在大型欧洲队列中检查年龄特异性危险因素与心房颤动 (AF) 及其归因分数的关联。此外，我们旨在检查与不同年龄的新发 AF 相关的卒中和死亡率风险。方法 我们使用来自 MOnica 风险、遗传学、档案和专着联盟的五个欧洲队列的个人水平数据（n = 66 951，49.1% 男性，基线年龄范围 40-98 岁）。参与者的 AF 事件跟踪长达 10 年，并与基线检查中可改变的危险因素（体重指数（BMI）、高血压、糖尿病、每日吸烟、饮酒以及中风和心肌梗塞（MI）病史）的关联) 进行了检查。此外，参与者在新发房颤后接受了卒中事件和全因死亡率的随访。结果 AF 发病率从基线年龄 40-49 岁的每 1000 人年 0.9 人增加到基线年龄≥70 岁的 17.7 人。多变量调整的 Cox 模型显示，较高的 BMI、高血压、大量饮酒以及有中风或 MI 病史与不同年龄组的 AF 风险增加相关（p<0.05）。30% 到 40% 的 AF 风险可归因于 BMI、高血压和中风或 MI 病史。新发房颤与年龄≥70 岁时卒中和死亡风险增加两倍相关（p≤0.001）。结论 在这个 40 岁及以上的大型欧洲队列中，AF 的风险主要归因于 BMI、高酒精消耗和中年以来的 MI 或中风病史。因此，房颤的预防措施应从小就针对肥胖和高血压等危险因素，并持续终生。数据在公共存储库中不可用。对数据的访问受到欧盟和每个 MORGAM 研究国家的伦理批准和立法的限制。每个队列研究的主要研究者和 MORGAM/BiomarCaRE 指导小组的批准都需要发布数据。MORGAM 手册位于 每个队列研究的主要研究者和 MORGAM/BiomarCaRE 指导小组的批准都需要发布数据。MORGAM 手册位于 每个队列研究的主要研究者和 MORGAM/BiomarCaRE 指导小组的批准都需要发布数据。MORGAM 手册位于提供有关访问数据的更多信息。