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Inhalation and deposition of spherical and pollen particles after middle turbinate resection in a human nasal cavity
Respiratory Physiology & Neurobiology ( IF 1.9 ) Pub Date : 2021-08-02 , DOI: 10.1016/j.resp.2021.103769
Kiao Inthavong 1 , Yidan Shang 1 , John M Del Gaudio 2 , Sarah K Wise 2 , Thomas S Edwards 2 , Kimberley Bradshaw 3 , Eugene Wong 3 , Murray Smith 3 , Narinder Singh 4
Affiliation  

Middle turbinate resection significantly alters the anatomy and redistributes the inhaled air. The superior half of the main nasal cavity is opened up, increasing accessibility to the region. This is expected to increase inhalation dosimetry to the region during exposure to airborne particles. This study investigated the influence of middle turbinate resection on the deposition of inhaled pollutants that cover spherical and non-spherical particles (e.g. pollen). A computational model of the nasal cavity from CT scans, and its corresponding post-operative model with virtual surgery performed was created. Two constant flow rates of 5 L/min, and 15 L/min were simulated under a laminar flow field. Inhaled particles including pollen (non-spherical), and a spherical particle with reference density of 1000 kg/m3 were introduced in the surrounding atmosphere. The effect of surgery was most prominent in the less patent cavity side, since the change in anatomy was proportionally greater relative to the original airway space. The left cavity produced an increase in particle deposition at a flow rate of 15 L/min. The main particle deposition mechanisms were inertial impaction, and to a lesser degree gravitational sedimentation. The results are expected to provide insight into inhalation efficiency of different aerosol types, and the likelihood of deposition in different nasal cavity surfaces.



中文翻译:

人鼻腔中鼻甲切除术后球形和花粉颗粒的吸入和沉积

中鼻甲切除显着改变了解剖结构并重新分配了吸入的空气。主鼻腔的上半部分被打开,增加了对该区域的可达性。预计这将增加暴露于空气传播颗粒期间该区域的吸入剂量测定。本研究调查了中鼻甲切除对覆盖球形和非球形颗粒(如花粉)的吸入污染物沉积的影响。建立了基于 CT 扫描的鼻腔计算模型,并创建了相应的带有虚拟手术的术后模型。在层流场下模拟了 5 L/min 和 15 L/min 的两个恒定流速。吸入颗粒,包括花粉(非球形)和参考密度为 1000 kg/m 的球形颗粒3被介绍到周围的气氛中。手术的效果在较少开放的腔侧最为突出,因为相对于原始气道空间,解剖结构的变化成比例地更大。左腔以 15 L/min 的流速产生颗粒沉积增加。主要的颗粒沉积机制是惯性撞击和较小程度的重力沉降。预计该结果将提供对不同气溶胶类型的吸入效率以及在不同鼻腔表面沉积的可能性的洞察。

更新日期:2021-08-07
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