Muscle stem cells (also called satellite cells or SCs) rely on their local niche for regulatory signals during homeostasis and regeneration. While a number of cell types communicate indirectly through secreted factors, here we focus on the significance of direct contact between SCs and their neighbors. During quiescence, SCs reside under a basal lamina and receive quiescence-promoting signals from their adjacent skeletal myofibers. Upon injury, the composition of the niche changes substantially, enabling the formation of new contacts that mediate proliferation, self-renewal, and differentiation. In this review, we summarize the latest work in understanding cell–cell contact within the satellite cell niche and highlight areas of open questions for future studies.

肌肉干细胞（也称为卫星细胞或 SC）在稳态和再生过程中依赖其局部生态位来提供调节信号。虽然许多细胞类型通过分泌因子间接沟通，但在这里我们重点关注 SC 与其邻居之间直接接触的重要性。在静止期间，SC 位于基底层下方，并接收来自相邻骨骼肌纤维的静止促进信号。损伤后，生态位的组成发生显着变化，从而能够形成介导增殖、自我更新和分化的新接触。在这篇综述中，我们总结了理解卫星细胞生态位内细胞间接触的最新工作，并强调了未来研究的开放问题领域。