In this study, a highly biocompatible adsorptive membrane is developed for haemodialysis application. Silica/α-mangostin hybrid nanoparticle was incorporated into polysulfone (PSf) based membrane to enhance the biocompatibility and the adsorption capacity of the membrane. The PSf based membranes were fabricated via dry-wet phase inversion technique and characterised based on scanning electron microscopy and contact angle measurement. The effects of silica/α-mangostin nanoparticle incorporation into PSf membrane were evaluated in terms of permeability, p-cresol adsorption capacity, urea, and creatinine removal capabilities, bovine serum albumin rejection and p-cresol dynamic adsorption. The biocompatibility assessment was done based on platelet adhesion, antioxidant properties, and complement activation of the membrane. The incorporation of the nanoparticle into PSf based membrane helped to smoothen the surface of the membrane and enhanced its hydrophilicity of the membrane by 12.54%. The presence of silica/α-mangostin in the membrane enhanced the adsorption capacity of the membrane by 20.92% with adsorption capacity of 55.64 mg/g at 500 mg/L initial concentration. The modified PSf membrane had also successfully improved the biocompatibility of the membrane by enhancing the scavenging activity of hydrogen peroxide and nitrogen oxide by 61.8% and 36%, respectively and inhibited the formation of C5a by 27.27%. The developed biocompatible PSf based adsorptive membrane has a good potential to be used for haemodialysis application.

在这项研究中，为血液透析应用开发了一种高度生物相容性的吸附膜。将二氧化硅/α-芒果苷杂化纳米颗粒掺入基于聚砜（PSf）的膜中，以提高膜的生物相容性和吸附能力。基于 PSf 的膜是通过干湿相转化技术制造的，并基于扫描电子显微镜和接触角测量进行表征。在渗透性、对甲酚吸附能力、尿素和肌酐去除能力、牛血清白蛋白排斥和对甲酚动态吸附方面评估了二氧化硅/α-山竹素纳米颗粒掺入 PSf 膜的影响。生物相容性评估是基于血小板粘附、抗氧化特性和膜的补体激活进行的。将纳米颗粒掺入基于 PSf 的膜有助于平滑膜表面，并将膜的亲水性提高 12.54%。膜中二氧化硅/α-芒果苷的存在使膜的吸附容量提高了20.92%，吸附容量为55.64  初始浓度为 500 mg/L 时的mg/g 。改性后的 PSf 膜还成功地提高了膜的生物相容性，将过氧化氢和氮氧化物的清除活性分别提高了 61.8% 和 36%，并抑制了 C5a 的形成 27.27%。开发的生物相容性 PSf 基吸附膜具有用于血液透析应用的良好潜力。