In many countries worldwide, the burden of hepatocellular carcinoma (HCC) associated with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is increasing. Preventive strategies are needed to counteract this trend. In this review, we provide an overview of the evidence on preventive strategies in NAFLD-associated HCC. We consider the impact of lifestyle factors such as weight loss, physical activity, smoking, dietary patterns and food items, including coffee and alcohol, on both HCC and NAFLD/NASH. Furthermore, evidence on chemopreventive treatments, including aspirin, antidiabetic treatments and statins is summarised. The role of adjuvant therapies for tertiary prevention of HCC is briefly reviewed.

在全球许多国家，与非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH) 相关的肝细胞癌 (HCC) 负担正在增加。需要采取预防策略来抵消这种趋势。在这篇综述中，我们概述了 NAFLD 相关 HCC 预防策略的证据。我们考虑生活方式因素的影响，例如减肥、体育锻炼、吸烟、饮食模式和食物，包括咖啡和酒精，对 HCC 和 NAFLD/NASH 的影响。此外，还总结了化学预防治疗的证据，包括阿司匹林、抗糖尿病治疗和他汀类药物。简要回顾了辅助治疗在 HCC 三级预防中的作用。