China is rich in primary energy resources. Due to specific terrain conditions, different types of problems may occur in the process of development. When the coal seams are located under the oil layers, due to the physical characteristics of oil, the exploitation of coal seams will cause losses to the oil layers, and the volatile oil may also cause threats to coal mining. To analyze the fracture development and leakage characteristics of overburden strata for this type of geological conditions, we have carried out physical simulation experiments and performed a further numerical simulation to study and verify the evolution of fractures. Based on numerical simulation results, methods have been proposed that may effectively reduce the air leakage in the working face and control the parameters, including viscous resistance, distance, and the construction period of the blocking. In this paper, based on the 30100 face in the Nanliang coal mine as an example, we have proved that the proposed measures can provide good theoretical guidance for the prevention of spontaneous combustion of residual coal and control of water in coal mine production. The developed method offers good economic benefits for safe production in coal mines.