Daldinins are a novel type of naturally occurring tricyclic heterocycles isolated from Daldinia concentrica. In this study, four daldinin A derivatives with different alkyl side chains were synthesized using the same synthetic protocol. Bioactivity tests first indicated that the daldinin A derivatives showed significant protection for endothelial cells against damage caused by high glucose. The derivative compound with three carbon atoms on the alkyl side exhibited the best effect.

Fullsize Image

中文翻译：

---

用于改善高血糖诱导的内皮细胞死亡的达尔地宁 A 衍生物的全合成、发现和生物学评价

Daldinins 是一种新型的天然存在的三环杂环化合物，从Daldinia concentrica 中分离出来。在本研究中，使用相同的合成方案合成了四种具有不同烷基侧链的 daldinin A 衍生物。生物活性测试首先表明，daldinin A 衍生物对内皮细胞具有显着的保护作用，可以防止高葡萄糖引起的损伤。烷基侧具有三个碳原子的衍生化合物表现出最好的效果。

全尺寸图像