A palladium-mediated intramolecular aryl–aryl coupling reaction was applied to the total synthesis of the bioactive natural products, graphislactone G (1), and palmariols A (2) and B (3), which possess an unusual chloro-subsutituent on the 6H-dibenzo[b,d]pyran-6-one skeleton. Based on the transition state model of the coupling reaction, the mechanistic aspect for the regioselectivity of the aryl–aryl coupling reaction is also discussed.

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中文翻译：

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氯代6H-二苯并[b,d]pyran-6-one天然产物、石墨内酯G和棕榈醇A和B的合成

钯介导的分子内芳基-芳基偶联反应被应用于生物活性天然产物石墨内酯 G ( 1 ) 和棕榈醇 A ( 2 ) 和 B ( 3 )的全合成，它们在 6 上具有不寻常的氯取代基。H- dibenzo[ b , d ]pyran-6-one 骨架。基于偶联反应的过渡态模型，还讨论了芳基-芳基偶联反应区域选择性的机理方面。

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