A 44-year-old previously healthy woman developed acute myelitis in close temporal relationship with ChAdOx1 nCoV-19 vaccine first-dose administration. The neurological involvement was mainly sensory with neuroimaging showing two mono-metameric lesions involving the posterior and lateral cord at dorsal level. Significant improvement was promptly recorded with high-dose intravenous steroids, with complete recovery within one month.

The strict temporal relationship between vaccination and myelitis, together with the absence of clues pointing to alternative diagnoses, might suggest a conceivable role for anti-SARS-CoV-2 vaccine as immunological trigger, although a causal relationship has yet to be established and our preliminary observation suggests caution.

一名 44 岁的既往健康女性患上急性脊髓炎与 ChAdOx1 nCoV-19 疫苗首剂接种有密切的时间关系。神经系统受累主要是感觉性的，神经影像学显示两个单同位素损伤，涉及背侧的后索和外侧索。大剂量静脉内类固醇迅速记录到显着改善，并在一个月内完全恢复。

疫苗接种和脊髓炎之间严格的时间关系，以及缺乏指向其他诊断的线索，可能表明抗 SARS-CoV-2 疫苗作为免疫触发因素的可能作用，尽管因果关系尚未确定，我们的初步观察表明谨慎。