The presented data clearly demonstrate that multinuclear MRI has a great potential in research and clinical fields. The biomedical value of many heavy nuclei that are part of drugs, contrast agents, and molecular complexes in live tissues emphasizes the need for creating and using MRI scanners tuned to the Larmor frequencies of such nuclei. This article discusses a number of specific problems solved with the use of multinuclear MRI. Since the sensitivity of the MRI on heavy nuclei, as a rule, is insufficient for obtaining images of satisfactory quality, it is proposed to use hyperpolarization techniques for preparing objects for the MRI diagnostics. However, bearing in mind the high cost of hyperpolarization techniques, alternative approaches using contrast agents normally absent in tissues can be more suitable in certain situations. For instance, due to the absence of fluorine in the body, ¹⁹F MRI allows for successful diagnostics of the respiratory tract and lungs filled with fluorine-containing gas, detecting the location of the blood substitute Perftoran® in the body, monitoring the transport along the gastrointestinal tract of a capsule filled with a preparation containing fluorine-19 nuclei, etc. The possibility of non-invasive local measurements of the concentration of sodium-23 in the body, which, in case of a deviation from the norm, is linked to such pathologies as diabetes, hypertension, renal failure, and many others, is also demonstrated. Reported as well is the creation of transmitting and receiving infrastructure that makes possible effective MRI measurements at low fields (of about 0.5 T) at 10 Larmor frequencies corresponding to the nuclei of hydrogen, deuterium, fluorine, boron, chlorine, sodium, carbon, phosphorus, silicon and oxygen.

所提供的数据清楚地表明，多核 MRI 在研究和临床领域具有巨大的潜力。作为药物、造影剂和活组织中分子复合物一部分的许多重核的生物医学价值强调了创建和使用调整到此类核的拉莫尔频率的 MRI 扫描仪的必要性。本文讨论了使用多核 MRI 解决的一些具体问题。由于 MRI 对重核的敏感性通常不足以获得令人满意的质量图像，因此建议使用超极化技术来准备用于 MRI 诊断的对象。然而，考虑到超极化技术的高成本，使用组织中通常不存在的造影剂的替代方法可能更适合某些情况。例如，¹⁹F MRI 可以成功诊断充满含氟气体的呼吸道和肺部，检测血液替代品 Perftoran® 在体内的位置，监测填充有氟 19 制剂的胶囊沿胃肠道的运输非侵入性局部测量体内钠 23 浓度的可能性，如果偏离标准，则与糖尿病、高血压、肾功能衰竭等疾病有关, 也证明了。还报道了发射和接收基础设施的创建，该基础设施可以在与氢、氘、氟、硼、氯、钠、碳、磷原子核相对应的 10 个拉莫尔频率的低场（约 0.5 T）下进行有效的 MRI 测量,