Abstract

Bis(indolyl) methane (BIM) derivatives have shown numerous biological properties which has influenced the scientific fraternity to explore the length and breadth of their synthesis. Mostly, the procedure involves a catalytic electrophilic substitution reaction of indoles with various aldehydes and ketones. However, many variations have been applied from time to time to promote this reaction under green conditions. The use of water as a solvent in organic synthesis, has gained much attention due to economic and eco-friendly reasons. It has also been observed that the reactions under aqueous conditions have shown high reactivities and chemo-selectivity, which are not found in organic media. “In water synthesis” of BIMs has gained considerable recent importance and several methods have been developed. Thus, in this review we have summarized different synthetic protocols used to prepare BIMs under aqueous conditions in the last fifteen years.

摘要

双（吲哚基）甲烷 (BIM) 衍生物显示出许多生物学特性，这影响了科学界探索其合成的长度和广度。大多数情况下，该过程涉及吲哚与各种醛和酮的催化亲电取代反应。然而，为了在绿色条件下促进这种反应，不时应用了许多变化。由于经济和环境友好的原因，在有机合成中使用水作为溶剂受到了广泛关注。还观察到，在水性条件下的反应显示出高反应性和化学选择性，这在有机介质中是没有的。BIM 的“水中合成”最近获得了相当大的重要性，并且已经开发了几种方法。因此，