Abstract

A novel and facile palladium-catalyzed annulation reaction between N-(8-quinolinyl) aryl carboxamides and 1-aryl-2-tosyloxy ethanones was herein demonstrated. The practical transformation took place readily in the presence of Pd(OAc)₂ without any ligands, offering the desired 3-aryl-2-(8-quinolinyl) isoquinolin-1(2H)-ones with good functional groups tolerance (29 examples) and high efficiencies (up to 90% yields). The mechanism of the protocol was proposed to take place through a C-H/N-H activation pathway, which was verified by the control reactions.

中文翻译：

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钯催化的 N-(8-喹啉基) 芳基甲酰胺与 1-芳基-2-甲苯磺酰氧基乙酮的氧化环化

摘要

本文证明了N- (8-喹啉基) 芳基甲酰胺和 1-芳基-2-甲苯磺酰氧基乙酮之间的新型和简便的钯催化环化反应。在没有任何配体的 Pd(OAc) ₂存在下，实际转化很容易发生，提供所需的 3-芳基-2-（8-喹啉基）异喹啉-1（2H）-酮，具有良好的官能团耐受性（29 个例子）和高效率（高达 90% 的产量）。该协议的机制被提议通过 CH/NH 激活途径发生, 这通过控制反应进行了验证。