Bipolar disorder (BD) is associated with a range of social cognitive deficits. This study investigated the functioning of the mentalizing brain system in BD probed by an eye gaze perception task during fMRI. Compared with healthy controls (n = 21), BD participants (n = 14) showed reduced preferential activation for self-directed gaze discrimination in the medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ), which was associated with poorer cognition/social cognition. Aberrant functions of the mentalizing system should be further investigated as marker of social dysfunction and treatment targets.

中文翻译：

---

双相情感障碍注视辨别过程中心智化大脑系统的异常激活

双相情感障碍 (BD) 与一系列社会认知缺陷有关。本研究调查了功能磁共振成像期间通过眼睛注视感知任务探测的 BD 中心智化大脑系统的功能。与健康对照组 ( n  = 21) 相比，BD 参与者 ( n  = 14) 在内侧前额叶皮层 (mPFC) 和颞顶叶交界处 (TPJ) 中的自我定向凝视辨别的优先激活减少，这与较差的认知能力有关/社会认知。精神化系统的异常功能应作为社会功能障碍和治疗目标的标志进一步研究。