Physical activity (PA) during pregnancy provides both maternal and fetal health benefits. It has been theorized that myokines, peptides secreted by contracting skeletal muscle, may play an important mechanistic role in facilitating the health benefits obtained from prenatal exercise. The objective of this review was to synthesize the current literature on the relationship between maternal PA and myokine response. A search strategy was developed using the terms pregnancy, PA, IL-6, IL-10, IL-13, and TNF-α. A systematic search was completed in July 2020, in Medline, SPORTDiscus, EMBASE, CENTRAL, and in November 2020 for unpublished dissertations (grey literature; Proquest). Both human- and animal-based studies of any design were included, while commentaries and editorial articles were excluded. Data were extracted by two independent reviewers and summarized narratively. Data were thematically summarized based on the myokine and whether findings were from human or animal studies. Ten studies were included in this review. Findings from studies that examined IL-6, IL-10, and TNF-α suggest a trimester-specific interaction between PA and myokine levels; no studies evaluated IL-13. Future research should investigate the PA-myokine relationship throughout all stages of gestation.

中文翻译：

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阐明整个妊娠期间母亲身体活动与循环肌因子之间的相互作用：范围审查

怀孕期间的体育活动 (PA) 对母体和胎儿的健康都有好处。有理论认为，肌肉因子（由骨骼肌收缩分泌的肽）可能在促进产前锻炼带来的健康益处方面发挥重要的机制作用。本综述的目的是综合当前关于母体 PA 与肌细胞因子反应之间关系的文献。使用术语怀孕、PA、IL-6、IL-10、IL-13 和 TNF-α 制定了搜索策略。2020 年 7 月在 Medline、SPORTDiscus、EMBASE、CENTRAL 和 2020 年 11 月完成了对未发表论文（灰色文献；Proquest）的系统搜索。任何设计的基于人类和动物的研究都包括在内，而评论和社论文章被排除在外。数据由两名独立审查员提取并进行叙述性总结。根据肌动因子以及研究结果是来自人类还是动物研究，对数据进行了专题总结。本综述纳入了十项研究。检查 IL-6、IL-10 和 TNF-α 的研究结果表明 PA 和肌因子水平之间存在妊娠期特异性相互作用；没有研究评估 IL-13。未来的研究应该调查整个妊娠阶段的 PA 与肌肉因子的关系。