A new type of embedded cyclic olefin copolymer microfluidic chip was designed and combined with terahertz (THz) technology to study the effects of glycine and arginine on the THz wave absorption characteristics. This study aims to understand the interactions between solid amino acid molecules and between amino acid and water molecules and to determine the changes in their microstructure. By observing the intensity of the time domain spectra in the range of 0.2–2.6 THz, we found that, as the concentration of glycine and arginine increased, the THz transmission gradually decreased. It can be inferred that the molecular structure and quantity of different amino acids have different influence on the hydrogen bond, which affects the absorption coefficient in solution. It was also found that the terahertz technique is able to identify the solid amino acid species better, and it can also perform some species identification for liquid amino acids. These results provide a reference for future studies on the terahertz absorption properties of amino acid samples. Moreover, Gaussian16 software was used to calculate the terahertz spectra using the density functional theory, B3LYP functional, and 6-31G basis set. Additionally, Gaussian View6 video software provided the frequency values, molecular vibration modes of the theoretical absorption peaks of glycine, arginine, and its aqueous solutions in the frequency range of 0.2–2.6 THz, which offers theoretical support for future studies.

中文翻译：

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两种固体氨基酸及其水溶液的太赫兹吸收特性

设计了一种新型嵌入式环烯烃共聚物微流控芯片，并结合太赫兹（THz）技术研究了甘氨酸和精氨酸对太赫兹波吸收特性的影响。本研究旨在了解固体氨基酸分子之间以及氨基酸与水分子之间的相互作用，并确定其微观结构的变化。通过观察0.2-2.6 THz范围内的时域光谱强度，我们发现随着甘氨酸和精氨酸浓度的增加，THz透射率逐渐降低。可以推断，不同氨基酸的分子结构和数量对氢键的影响不同，从而影响溶液中的吸收系数。还发现太赫兹技术能够更好地识别固体氨基酸种类，也可以对液体氨基酸进行一些种类识别。这些结果为今后氨基酸样品太赫兹吸收特性的研究提供了参考。此外，Gaussian16 软件用于使用密度泛函理论、B3LYP 泛函和 6-31G 基组计算太赫兹光谱。此外，Gaussian View6视频软件提供了甘氨酸、精氨酸及其水溶液在0.2-2.6 THz频率范围内的理论吸收峰的频率值、分子振动模式，为后续研究提供了理论支持。这些结果为今后氨基酸样品太赫兹吸收特性的研究提供了参考。此外，Gaussian16 软件用于使用密度泛函理论、B3LYP 泛函和 6-31G 基组计算太赫兹光谱。此外，Gaussian View6视频软件提供了甘氨酸、精氨酸及其水溶液在0.2-2.6 THz频率范围内的理论吸收峰的频率值、分子振动模式，为后续研究提供了理论支持。这些结果为今后氨基酸样品太赫兹吸收特性的研究提供了参考。此外，Gaussian16 软件用于使用密度泛函理论、B3LYP 泛函和 6-31G 基组计算太赫兹光谱。此外，Gaussian View6视频软件提供了甘氨酸、精氨酸及其水溶液在0.2-2.6 THz频率范围内的理论吸收峰的频率值、分子振动模式，为后续研究提供了理论支持。