This cross-sectional study is aimed at assessing the effects of opium use disorder (OUD) on attention, working memory, and information-processing speed. Thirty outpatients with OUD and 20 healthy controls (HCs) were assessed using a neuropsychological battery consisted of Auditory Verbal Learning Test-Revised (AVLT-R), Brief Visuospatial Memory Test-Revised (BVMT-R), Digit Forward and Backward Tests (DFT and DBT), and WAIS-R Digit Symbol Substitution Test (DSST). The most affected cognitive functions in patients with OUD were detected by DBT and DSST. However, we found no significant difference between patients according to the route of administration. Within patients with OUD, DBT score was associated with opium use quantity (OUQ) (), and DBT () and DSST () scores were correlated with duration of use. Our findings indicated that working memory and information-processing speed are the most affected domains of cognitive functioning. DBT and DSST could be used as brief assessments in clinical settings to screen for cognitive deficits in patients with OUD.

中文翻译：

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鸦片使用障碍的认知障碍

这项横断面研究旨在评估鸦片使用障碍 (OUD) 对注意力、工作记忆和信息处理速度的影响。30 名患有 OUD 的门诊患者和 20 名健康对照 (HC) 使用由听觉语言学习测试修订版 (AVLT-R)、简短视觉空间记忆测试修订版 (BVMT-R)、数字向前和向后测试 (DFT) 组成的神经心理学电池组进行评估和 DBT)，以及 WAIS-R 数字符号替换测试 (DSST)。通过 DBT 和 DSST 检测到 OUD 患者中受影响最大的认知功能。然而，我们发现根据给药途径，患者之间没有显着差异。在 OUD 患者中，DBT 评分与鸦片使用量（OUQ）相关（)和 DBT ()和 DSST ()分数与使用持续时间相关。我们的研究结果表明，工作记忆和信息处理速度是认知功能受影响最大的领域。DBT 和 DSST 可用作临床环境中的简要评估，以筛查 OUD 患者的认知缺陷。