Vitamin D plays an important role in both the innate and adaptive immune systems. We review published data on the relationship between uveitis and vitamin D levels or vitamin D-associated gene polymorphisms. A search of the PubMed and Medline databases was conducted to identify relevant articles concerning vitamin D and uveitis. Sixteen studies were included in this review, and the evidence they present, linking low vitamin D levels with uveitis, is compelling. The uveitic entities shown to be modulated by hypovitaminosis D include, but are not limited to, HLA-B27-associated acute anterior uveitis, Vogt-Koyanagi-Harada (VKH) disease, sarcoidosis-associated uveitis, and juvenile idiopathic arthritis-associated uveitis. Specific polymorphisms of vitamin D family genes were found to correlate with uveitis in ankylosing spondylitis, Behçet's disease, VKH, and HLA B27-positive patients. Further understanding of the role of vitamin D, a known regulator of inflammatory processes, in noninfectious uveitis may advance capabilities in the fields of disease prevention and treatment.

维生素 D 在先天和适应性免疫系统中都发挥着重要作用。我们回顾了已发表的关于葡萄膜炎与维生素 D 水平或维生素 D 相关基因多态性之间关系的数据。对 PubMed 和 Medline 数据库进行了搜索，以确定有关维生素 D 和葡萄膜炎的相关文章。这篇综述纳入了 16 项研究，他们提出的将维生素 D 水平低与葡萄膜炎联系起来的证据令人信服。显示受维生素缺乏症 D 调节的葡萄膜炎实体包括但不限于 HLA-B27 相关的急性前葡萄膜炎、Vogt-Koyanagi-Harada (VKH) 病、结节病相关的葡萄膜炎和幼年特发性关节炎相关的葡萄膜炎。发现维生素 D 家族基因的特定多态性与强直性脊柱炎中的葡萄膜炎相关，Behçet' s 病、VKH 和 HLA B27 阳性患者。进一步了解维生素 D（一种已知的炎症过程调节剂）在非感染性葡萄膜炎中的作用可能会提高疾病预防和治疗领域的能力。