Dopamine type 2 receptor (D2R) agonists have anticonvulsant effect, whereas D2R antagonists increase seizure risk, but the mechanism of this action has not been delineated. We tested whether D2R agonists activate parvalbumin (PV)-containing inhibitory interneurons to suppress seizures. We treated frontal lobe onset seizures with a D2R agonist sumanirole, and it suppressed seizures. We used activity reporter TRAP2 mice and found that injection of D2R agonist led to extensive activation of PV interneurons in the cortex and striatum ipsilateral to the seizure focus. D2R agonists activate PV interneurons, which in turn inhibit principal neurons, potentially explaining their anticonvulsant effect.

中文翻译：

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抗惊厥药多巴胺 2 型受体激动剂激活抑制性小白蛋白中间神经元

多巴胺 2 型受体 (D2R) 激动剂具有抗惊厥作用，而 D2R 拮抗剂会增加癫痫发作的风险，但这种作用的机制尚未阐明。我们测试了 D2R 激动剂是否激活含有小白蛋白 (PV) 的抑制性中间神经元以抑制癫痫发作。我们用 D2R 激动剂 sumaniro 治疗了额叶发作的癫痫发作，它抑制了癫痫发作。我们使用了活动报告器 TRAP2 小鼠，发现注射 D2R 激动剂导致癫痫病灶同侧的皮质和纹状体中的 PV 中间神经元广泛激活。D2R 激动剂激活 PV 中间神经元，进而抑制主要神经元，这可能解释了它们的抗惊厥作用。