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Review on marine sponge alkaloid, aaptamine: A potential antibacterial and anticancer drug
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2021-07-31 , DOI: 10.1111/cbdd.13932 Vinita Manimaran Nadar 1 , Selvambigai Manivannan 1 , Rajasekar Chinnaiyan 2 , Muthusamy Govarthanan 3 , Kumar Ponnuchamy 1
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2021-07-31 , DOI: 10.1111/cbdd.13932 Vinita Manimaran Nadar 1 , Selvambigai Manivannan 1 , Rajasekar Chinnaiyan 2 , Muthusamy Govarthanan 3 , Kumar Ponnuchamy 1
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In recent years, biological macromolecules have piqued the interest of researchers owing to their vast variety of biological uses. As a result, the marine sponge is a multicellular heterotrophic parazoan with chemicals for defence against predator assaults, biofouling and microbial diseases. These priceless molecules are known as secondary metabolites, and they are essential for survival in a highly competitive environment. So far, over 5,000 marine natural compounds have been extracted from marine sponges, making them an excellent option for drug formulation. One among them is, aaptamine, a marine alkaloid with a benzo[de][1,6]-napthyridine framework extensively distributed in marine sponges. Due to this reason, aaptamine has been intensively researched for various biological purposes, including cancer and protease inhibition, offering fresh insights into novel treatments. Keeping this in mind, we reviewed the biological significance of the marine sponge alkaloid aaptamine.
中文翻译：
海绵生物碱、aaptamine：一种潜在的抗菌抗癌药物综述
近年来，生物大分子因其广泛的生物学用途而引起了研究人员的兴趣。因此，海绵是一种多细胞异养寄生虫，含有用于防御捕食者攻击、生物污染和微生物疾病的化学物质。这些无价的分子被称为次级代谢物，它们对于在竞争激烈的环境中生存至关重要。迄今为止，已从海绵中提取了超过 5,000 种海洋天然化合物，使其成为药物制剂的绝佳选择。其中之一是 aaptamine，一种具有苯并[de][1,6]-萘啶骨架的海洋生物碱，广泛分布在海绵中。由于这个原因，aaptamine 已被深入研究用于各种生物学目的，包括癌症和蛋白酶抑制，提供对新疗法的新见解。牢记这一点，我们回顾了海绵生物碱 aaptamine 的生物学意义。
更新日期：2021-07-31
中文翻译：
海绵生物碱、aaptamine：一种潜在的抗菌抗癌药物综述
近年来，生物大分子因其广泛的生物学用途而引起了研究人员的兴趣。因此，海绵是一种多细胞异养寄生虫，含有用于防御捕食者攻击、生物污染和微生物疾病的化学物质。这些无价的分子被称为次级代谢物，它们对于在竞争激烈的环境中生存至关重要。迄今为止，已从海绵中提取了超过 5,000 种海洋天然化合物，使其成为药物制剂的绝佳选择。其中之一是 aaptamine，一种具有苯并[de][1,6]-萘啶骨架的海洋生物碱，广泛分布在海绵中。由于这个原因，aaptamine 已被深入研究用于各种生物学目的，包括癌症和蛋白酶抑制，提供对新疗法的新见解。牢记这一点，我们回顾了海绵生物碱 aaptamine 的生物学意义。
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