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Viral-induced inflammatory coagulation disorders: Preparing for another epidemic
Thrombosis and Haemostasis ( IF 5.0 ) Pub Date : 2021-07-30 , DOI: 10.1055/a-1562-7599
Toshiaki Iba 1 , Jerrold H Levy 2 , Marcel Levi 3
Affiliation  

A number of viral infectious diseases have emerged or reemerged from wildlife vectors that have generated serious threats to global health. Increased international traveling and commerce increase the risk of transmission of viral or other infectious diseases. In addition, recent climate changes accelerate the potential spread of domestic disease. The Coronavirus disease 2019 (COVID-19) pandemic is an important example of the worldwide spread, and the current epidemic will unlikely be the last. Viral hemorrhagic fevers, such as Dengue and Lassa fevers, may also have the potential to spread worldwide with a significant impact on public health with unpredictable timing. Based on the important lessons learned from COVID-19, it would be prudent to prepare for future pandemics of life-threatening viral diseases. Among the various threats, this review focuses on the coagulopathy of acute viral infections since hypercoagulability has been a major challenge in COVID-19, but represents a different presentation compared to viral hemorrhagic fever. However, both thrombosis and hemorrhage are understood as the result of thromboinflammation due to viral infections, and the role of anticoagulation is important to consider.

中文翻译:

病毒引起的炎症性凝血障碍:为另一场流行病做准备

许多病毒性传染病已经从野生动物媒介中出现或重新出现,对全球健康产生了严重威胁。增加的国际旅行和商业增加了病毒或其他传染病传播的风险。此外,最近的气候变化加速了国内疾病的潜在传播。2019 年冠状病毒病 (COVID-19) 大流行是全球传播的一个重要例子,当前的流行病不太可能是最后一次。病毒性出血热,如登革热和拉沙热,也有可能在世界范围内传播,对公共卫生产生重大影响,而且时间不可预测。基于从 COVID-19 中汲取的重要经验教训,谨慎应对未来威胁生命的病毒性疾病的大流行。在各种威胁中,本综述重点关注急性病毒感染的凝血功能障碍,因为高凝状态一直是 COVID-19 的主要挑战,但与病毒性出血热相比呈现不同的表现。然而,血栓形成和出血都被理解为由病毒感染引起的血栓炎症的结果,抗凝的作用是需要考虑的重要因素。
更新日期:2021-09-10
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