Nephrotoxic impacts of Al₂O₃ nanoparticles (NPs) were studied in Oreochromis niloticus after seven days of exposure and fifteen days of recovery periods. Fish were classified as group I (dechlorinated water); group II (2 mg/L Al₂O₃NPs); group III (4 mg/L Al₂O₃NPs); group IV (8 mg/L Al₂O₃NPs). Blood creatinine and uric acid levels showed marked increases in groups III and IV. A dose-dependent disturbance in renal antioxidant components was recorded as indicated by elevated catalase, superoxide dismutase, thiobarbituric acid reactive substances levels, and decreased glutathione reduced concentration. Renal histopathology was recorded with the highest % of appearance in group IV. A reduction in renal Al content, kidney function biomarkers (excepting group IV), and enhanced antioxidant status were observed after applying a recovery strategy. Several structural damages were identified following the recovery period, but the alteration frequencies indicated regressive histopathological changes. The Al₂O₃NPs-induced nephrotoxicity can be reduced after applying a suitable recovery period.

在暴露 7 天和恢复期 15 天后，在尼罗罗非鱼中研究了 Al ₂ O ₃纳米颗粒 (NPs) 的肾毒性影响。鱼被归类为 I 组（脱氯水）；第二组（2 mg/L Al ₂ O ₃ NPs）；第三组（4 mg/L Al ₂ O ₃ NPs）；第四组（8 mg/L Al ₂ O ₃NP）。III 组和 IV 组的血肌酐和尿酸水平显着升高。如过氧化氢酶、超氧化物歧化酶、硫代巴比妥酸反应物质水平升高和谷胱甘肽降低浓度降低所示，记录了肾脏抗氧化成分的剂量依赖性紊乱。肾脏组织病理学记录在第 IV 组中出现的百分比最高。在应用恢复策略后，观察到肾 Al 含量、肾功能生物标志物（IV 组除外）和抗氧化状态增强。恢复期后发现了几种结构性损伤，但改变频率表明组织病理学发生退行性变化。铝₂ O ₃应用适当的恢复期后，可以减少 NPs 引起的肾毒性。