RNA modification of an RNA modifier prevents self-RNA sensing.,PLOS Biology

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RNA modification of an RNA modifier prevents self-RNA sensing.
PLOS Biology ( IF 9.8 ) Pub Date : 2021-07-30 , DOI: 10.1371/journal.pbio.3001342
Daltry L Snider ₁ , Stacy M Horner _{1,

2}

Affiliation

A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 (MDA5)-mediated host antiviral response.

中文翻译：

RNA 修饰剂的 RNA 修饰可防止自身 RNA 感应。

PLOS Biology 的一项新研究发现，干扰素 (IFN) 诱导的腺苷脱氨酶作用于 RNA 1 (ADAR1) mRNA 是经过 N6-甲基腺苷 (m6A) 修饰以促进其翻译，从而使 ADAR1 能够修饰自身双链 RNA (dsRNA)在 IFN 反应期间产生并阻止黑色素瘤分化相关蛋白 5 (MDA5) 介导的宿主抗病毒反应的激活。

更新日期：2021-07-30

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