Genome-wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy,FEBS Letters

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Genome-wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy
FEBS Letters ( IF 3.0 ) Pub Date : 2021-07-30 , DOI: 10.1002/1873-3468.14168
Fangfang Wang ₁ , Jieqiong Zhao ₁ , Mingming Zhang ₁ , Jingxiao Yang ₁ , Guangwei Zeng _{1,

2}

Affiliation

LIM-domain proteins have been shown to be associated with heart development and diseases. Systematic studies of LIM family members at the genome-wide level, which are crucial to further understand their functions in cardiac hypertrophy, are currently lacking. Here, 70 LIM genes were identified and characterised in mice. The expression patterns of LIM genes differ greatly during cardiac development and in the case of hypertrophy. Both Crip2 and Xirp2 are differentially expressed in cardiac hypertrophy and during heart failure. In addition, the hypertrophic state of cardiomyocytes is controlled by the relative expression levels of Crip2 and Xirp2. This study provides a foundation for further understanding of the special roles of LIM proteins in mammalian cardiac development and hypertrophy.

中文翻译：

小鼠 LIM 基因家族的全基因组分析揭示了其在调节病理性心脏肥大中的作用

LIM 结构域蛋白已被证明与心脏发育和疾病相关。目前缺乏对 LIM 家族成员在全基因组水平上的系统研究，这对于进一步了解其在心脏肥大中的功能至关重要。在此，我们在小鼠体内鉴定并表征了 70 个 LIM 基因。 LIM 基因的表达模式在心脏发育过程中和肥厚情况下有很大差异。 Crip2 和 Xirp2 在心脏肥大和心力衰竭期间都有差异表达。此外，心肌细胞的肥大状态受Crip2和Xirp2的相对表达水平控制。该研究为进一步了解LIM蛋白在哺乳动物心脏发育和肥大中的特殊作用奠定了基础。

更新日期：2021-09-13

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