The aim of our study was to investigate the effects of one-month consumption of polyphenol-rich standardized Aronia melanocarpa extract (SAE) on redox status in anemic hemodialysis patients. The study included 30 patients (Hb < 110 g/l, hemodialysis or hemodiafiltration > 3 months; > 3 times week). Patients were treated with commercially available SAE in a dose of 30 ml/day, for 30 days. After finishing the treatment blood samples were taken to evaluate the effects of SAE on redox status. Several parameters of anemia and inflammation were also followed. After the completion of the treatment, the levels of superoxide anion radical and nitrites significantly dropped, while the antioxidant capacity improved via elevation of catalase and reduced glutathione. Proven antioxidant effect was followed by beneficial effects on anemia parameters (increased hemoglobin and haptoglobin concentration, decreased ferritin and lactate dehydrogenase concentration), but SAE consumption didn't improve inflammatory status, except for minor decrease in C-reactive protein. The consumption of SAE regulates redox status (reduce the productions of pro-oxidative molecules and increase antioxidant defense) and has beneficial effects on anemia parameters. SAE could be considered as supportive therapy in patients receiving hemodialysis which are prone to oxidative stress caused by both chronic kidney disease and hemodialysis procedure. Additionally, it could potentially be a good choice for supplementation of anemic hemodialysis patients. TRN: NCT04208451 December 23, 2019 “retrospectively registered”

我们研究的目的是调查一个月食用富含多酚的标准化Aronia melanocarpa的影响提取物（SAE）对贫血血液透析患者氧化还原状态的影响。该研究包括 30 名患者（Hb < 110 g/l，血液透析或血液透析滤过 > 3 个月；> 每周 3 次）。患者接受市售 SAE 治疗，剂量为 30 毫升/天，持续 30 天。治疗结束后采集血样以评估 SAE 对氧化还原状态的影响。还跟踪了贫血和炎症的几个参数。处理完成后，超氧阴离子自由基和亚硝酸盐水平显着下降，而抗氧化能力通过过氧化氢酶和还原型谷胱甘肽的升高而提高。经证实的抗氧化作用之后是对贫血参数的有益作用（增加血红蛋白和触珠蛋白浓度，降低铁蛋白和乳酸脱氢酶浓度），但 SAE 的消耗并没有改善炎症状态，除了 C 反应蛋白的轻微下降。SAE 的消耗可调节氧化还原状态（减少促氧化分子的产生并增加抗氧化防御）并对贫血参数产生有益影响。SAE可被视为接受血液透析患者的支持治疗，这些患者容易因慢性肾脏病和血液透析程序引起的氧化应激。此外，它可能是补充贫血血液透析患者的好选择。TRN: NCT04208451 2019年12月23日“追溯注册” SAE 的消耗可调节氧化还原状态（减少促氧化分子的产生并增加抗氧化防御）并对贫血参数产生有益影响。SAE可被视为接受血液透析患者的支持治疗，这些患者容易因慢性肾脏病和血液透析程序引起的氧化应激。此外，它可能是补充贫血血液透析患者的好选择。TRN: NCT04208451 2019年12月23日“追溯注册” SAE 的消耗可调节氧化还原状态（减少促氧化分子的产生并增加抗氧化防御）并对贫血参数产生有益影响。SAE可被视为接受血液透析患者的支持治疗，这些患者容易因慢性肾脏病和血液透析程序引起的氧化应激。此外，它可能是补充贫血血液透析患者的好选择。TRN: NCT04208451 2019年12月23日“追溯注册” 它可能是补充贫血血液透析患者的一个不错的选择。TRN: NCT04208451 2019年12月23日“追溯注册” 它可能是补充贫血血液透析患者的一个不错的选择。TRN: NCT04208451 2019年12月23日“追溯注册”