Coronavirus disease 2019 (COVID-19) is still exerting a great influence on global health and economy. The initial fight against COVID-19 relied mainly on non-pharmacological measures, including social distancing, facial masks, active screening and isolation, etc. In terms of pharmacological interventions, huge progress has been made in the development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), although the appearance of several mutant variants has raised concerns for lasting immunity. The repurposing of established drugs has been another strategy to search for weapons in treatment or prophylaxis against COVID-19. Although immuno-modulating drugs, including corticosteroids, have been demonstrated to have therapeutic effects, no anti-viral medications have so far been shown to be protective.

2019 年冠状病毒病 (COVID-19) 仍在对全球健康和经济产生重大影响。最初与 COVID-19 的斗争主要依靠非药物措施，包括保持社交距离、戴口罩、主动筛查和隔离等. 在药物干预方面，针对严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 的疫苗开发取得了巨大进展，尽管几种突变变体的出现引发了人们对持久免疫的担忧。对既定药物进行再利用是寻找治疗或预防 COVID-19 武器的另一种策略。尽管包括皮质类固醇在内的免疫调节药物已被证明具有治疗作用，但迄今为止还没有抗病毒药物被证明具有保护作用。