Background

Ovarian cancer is one of the most prevalent cancers with a high mortality rate in women. Published studies indicate that inflammation, DNA damage, and pelvic inflammatory disease (PID) are the most important risk factors for ovarian cancer and this could be induced and exacerbated by infectious agents such as Chlamydia trachomatis and Mycoplasma genitalium. The aim of this study was to determine the association between Chlamydia and Mycoplasma infections and the risk of ovarian cancer.

Methods

We carried out a comprehensive search of PubMed, Scopus, Web of Science, Embase, and Google Scholar without limitation on publication date. All relevant studies which investigatived probable potential connection between Chlamydia and Mycoplasma infection and development of ovarian cancer were included.

Results

Eighteen studies comprising a total of 8,207 patients were evaluated in the study and this showed that the frequency of infection with Chlamydia and Mycoplasma among ovarian cancer patients was 32.6% and 23%, respectively. The results suggested that Chlamydia trachomatis infection increased the overall risk for ovarian cancer by 1.344 fold (OR: 1.344; 95%CI: 1.19-1.50). Moreover, infection with Mycoplasma infections showed a week but not significant increased risk of ovarian cancer (OR: 1.12; 95%CI: 0.86-1.44). However, the test for heterogeneity was significant among these studies.

Conclusion

This study confirmed the clinical relevance of Chlamydia and Mycoplasma infection and development of the ovarian cancer risk, although the significance was marginal and study heterogeneity was significant. This highlights the need for further studies in this area.

中文翻译：

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衣原体和支原体感染与卵巢癌易感性的关联：系统评价和荟萃分析

背景

卵巢癌是女性最常见的癌症之一，死亡率很高。已发表的研究表明，炎症、DNA 损伤和盆腔炎 (PID) 是卵巢癌最重要的危险因素，沙眼衣原体和生殖支原体等感染因子可诱发和加剧这种情况。本研究的目的是确定衣原体和支原体感染与卵巢癌风险之间的关联。

方法

我们对 PubMed、Scopus、Web of Science、Embase 和 Google Scholar 进行了全面检索，不限制出版日期。所有调查衣原体和支原体感染与卵巢癌发展之间可能的潜在联系的相关研究都包括在内。

结果

该研究评估了 8,207 名患者的 18 项研究，结果表明卵巢癌患者感染衣原体和支原体的频率分别为 32.6% 和 23%。结果表明，沙眼衣原体感染使卵巢癌的总体风险增加了 1.344 倍（OR：1.344；95%CI：1.19-1.50）。而且，感染支原体感染一周但未显着增加患卵巢癌的风险（OR：1.12；95%CI：0.86-1.44）。然而，这些研究中的异质性检验很重要。

结论

这项研究证实了衣原体和支原体感染与卵巢癌风险的发展之间的临床相关性，尽管其意义微乎其微且研究异质性显着。这凸显了在该领域进一步研究的必要性。