Abstract

Natural polymeric scaffolds can be used for tissue engineering applications such as cell delivery and cell-free supporting of native tissues. This is because of their desirable properties such as; high biocompatibility, tunable mechanical strength and conductivity, large surface area, porous- and extracellular matrix (ECM)-mimicked structures. Specifically, their less toxicity and biocompatibility makes them suitable for several tissue engineering applications. For these reasons, several biopolymeric scaffolds are currently being explored for numerous tissue engineering applications. To date, research on the nature, chemistry, and properties of nanocomposite biopolymers are been reported, while the need for a comprehensive research note on more tissue engineering application of these biopolymers remains. As a result, this present study comprehensively reviews the development of common natural biopolymers as scaffolds for tissue engineering applications such as cartilage tissue engineering, cornea repairs, osteochondral defect repairs, and nerve regeneration. More so, the implications of research findings for further studies are presented, while the impact of research advances on future research and other specific recommendations are added as well.

摘要

天然聚合物支架可用于组织工程应用，例如细胞递送和天然组织的无细胞支持。这是因为它们具有理想的特性，例如；高生物相容性、可调节的机械强度和电导率、大表面积、多孔和细胞外基质 (ECM) 模拟结构。具体而言，它们较低的毒性和生物相容性使其适用于多种组织工程应用。由于这些原因，目前正在探索多种生物聚合物支架用于许多组织工程应用。迄今为止，已经报道了对纳米复合生物聚合物的性质、化学和性质的研究，同时仍然需要一份关于这些生物聚合物的更多组织工程应用的综合研究报告。因此，本研究全面回顾了常见的天然生物聚合物作为组织工程应用支架的发展，如软骨组织工程、角膜修复、骨软骨缺损修复和神经再生。更重要的是，介绍了研究结果对进一步研究的影响，同时还增加了研究进展对未来研究的影响和其他具体建议。