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Stimulation of Innate and Adaptive Immune Cells with Graphene Oxide and Reduced Graphene Oxide Affect Cancer Progression
Archivum Immunologiae et Therapiae Experimentalis ( IF 2.9 ) Pub Date : 2021-07-29 , DOI: 10.1007/s00005-021-00625-6
Muhammad Amir Yunus 1 , Muhammad Mahyiddin Ramli 2, 3 , Nurul Huda Osman 4 , Rafeezul Mohamed 5
Affiliation  

Sole nanomaterials or nanomaterials bound to specific biomolecules have been proposed to regulate the immune system. These materials have now emerged as new tools for eliciting immune-based therapies to treat various cancers. Graphene, graphene oxide (GO) and reduced GO (rGO) are the latest nanomaterials among other carbon nanotubes that have attracted wide interest among medical industry players due to their extraordinary properties, inert-state, non-toxic and stable dispersion in a various solvent. Currently, GO and rGO are utilized in various biomedical application including cancer immunotherapy. This review will highlight studies that have been carried out in elucidating the stimulation of GO and rGO on selected innate and adaptive immune cells and their effect on cancer progression to shed some insights for researchers in the development of various GO- and rGO-based immune therapies against various cancers.



中文翻译:

用氧化石墨烯刺激先天和适应性免疫细胞和减少氧化石墨烯影响癌症进展

已经提出单独的纳米材料或与特定生物分子结合的纳米材料来调节免疫系统。这些材料现在已成为引发基于免疫疗法来治疗各种癌症的新工具。石墨烯、氧化石墨烯 (GO) 和还原型 GO (rGO) 是其他碳纳米管中最新的纳米材料,由于其非凡的特性、惰性状态、无毒和在各种溶剂中的稳定分散性,引起了医疗行业参与者的广泛兴趣. 目前,GO 和 rGO 被用于各种生物医学应用,包括癌症免疫治疗。

更新日期:2021-07-30
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