A typical consequence of stroke in the right hemisphere is unilateral spatial neglect. Distinct forms of neglect have been described, such as space-based (egocentric) and object-based (allocentric) neglect. However, the relationship between these two forms of neglect is still far from being understood, as well as their neural substrates. Here, we further explore this issue by using voxel lesion symptoms mapping (VLSM) analyses on a large sample of early subacute right-stroke patients assessed with the Apples Cancellation Test. This is a sensitive test that simultaneously measures both egocentric and allocentric neglect. Behaviourally, we found no correlation between egocentric and allocentric performance, indicating independent mechanisms supporting the two forms of neglect. This was confirmed by the VLSM analysis that pointed out a link between a damage in the superior longitudinal fasciculus and left egocentric neglect. By contrast, no association was found between brain damage and left allocentric neglect. These results indicate a higher probability to observe egocentric neglect as a consequence of white matter damages in the superior longitudinal fasciculus, while allocentric neglect appears more “globally” related to the whole lesion map. Overall, these findings on early subacute right-stroke patients highlight the role played by white matter integrity in sustaining attention-related operations within an egocentric frame of reference.

右半球中风的典型后果是单方面的空间忽视。已经描述了不同形式的忽视，例如基于空间的（以自我为中心的）和基于对象的（以自我为中心的）忽视。然而，这两种形式的忽视之间的关系以及它们的神经基础仍然远未得到理解。在这里，我们通过对使用 Apples Cancellation Test 评估的大量早期亚急性右脑卒中患者的大样本进行体素病变症状映射 (VLSM) 分析，进一步探讨了这个问题。这是一项敏感的测试，可以同时测量以自我为中心和以异能为中心的忽视。在行为上，我们发现以自我为中心和以异能为中心的表现之间没有相关性，表明支持这两种形式的忽视的独立机制。VLSM 分析证实了这一点，该分析指出了上纵束损伤与左侧以自我为中心的忽视之间的联系。相比之下，没有发现脑损伤与左侧异中心忽视之间存在关联。这些结果表明，由于上纵束白质损伤，观察到以自我为中心的忽视的可能性更高，而异中心的忽视似乎更“全局”地与整个病变图相关。总体而言，这些关于早期亚急性右卒中患者的研究结果突出了白质完整性在以自我为中心的参考框架内维持与注意力相关的操作中所起的作用。这些结果表明，由于上纵束白质损伤，观察到以自我为中心的忽视的可能性更高，而异中心的忽视似乎更“全局”地与整个病变图相关。总体而言，这些关于早期亚急性右卒中患者的研究结果突出了白质完整性在以自我为中心的参考框架内维持与注意力相关的操作中所起的作用。这些结果表明，由于上纵束白质损伤，观察到以自我为中心的忽视的可能性更高，而异中心的忽视似乎更“全局”地与整个病变图相关。总体而言，这些关于早期亚急性右卒中患者的研究结果突出了白质完整性在以自我为中心的参考框架内维持与注意力相关的操作中所起的作用。