Cells coexist together in colonies or as tissues. Their behavior is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network controlling growth and division, and couple this to the physical forces arising within the cell collective. We analyze this model using both particle-based computer simulations and a continuum theory. We focus on 2D colonies confined in a channel. These develop moving growth fronts of dividing cells with quiescent cells in the interior. The profile and speed of these fronts are nontrivially related to the substrate friction and the cell-cycle parameters, providing a possible approach to measure such parameters in experiments.

中文翻译：

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细胞周期在集体细胞动力学中的作用

细胞在菌落中或作为组织共存。它们的行为受细胞间力和生化调节之间的相互作用控制。我们开发了一个简单的细胞周期模型，它是控制生长和分裂的基本调节网络，并将其与细胞群内产生的物理力相结合。我们使用基于粒子的计算机模拟和连续理论来分析该模型。我们专注于限制在通道中的 2D 菌落。这些在分裂细胞的内部形成静止细胞的移动生长前沿。这些前沿的轮廓和速度与基底摩擦和细胞周期参数密切相关，为在实验中测量这些参数提供了一种可能的方法。