Routine high-precision Nd isotope analyses: an optimized chromatographic purification scheme,Journal of Analytical Atomic Spectrometry

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Routine high-precision Nd isotope analyses: an optimized chromatographic purification scheme
Journal of Analytical Atomic Spectrometry ( IF 3.1 ) Pub Date : 2021-07-30 , DOI: 10.1039/d1ja00169h
Eugenia Hyung ₁ , François L. H. Tissot ₁

Affiliation

High-precision Nd isotope measurements provide key constraints on the evolution of the silicate Earth and planetary bodies. As advances in mass-spectrometry and measurement techniques have brought the precision of ¹⁴²Nd/¹⁴⁴Nd measurements down to ±2 ppm (parts-per-million), systematic biases stemming from insufficient sample purification (matrix effects and/or isobaric interferences) or non-quantitative yields are becoming increasingly problematic. One of the most widespread approaches for Nd purification uses cation-exchange column chromatography with α-HIBA (2-methylactic acid) reagent. Despite its popularity, limitations pertaining to the level of purification and yield of the α-HIBA method exist. Here we present an optimized α-HIBA purification protocol that addresses these limitations and achieves the level of purity required for routine high-precision Nd isotope analyses. This protocol builds on existing methodologies and a comprehensive series of tests that we performed, and efficiently minimizes procedural blanks, the number of column passes, and thus the sample processing time, while maximizing recovery yields. We anticipate that this optimized protocol will benefit both established and new users of the α-HIBA column chromatography method.

中文翻译：

常规高精度 Nd 同位素分析：优化的色谱纯化方案

高精度 Nd 同位素测量为硅酸盐地球和行星体的演化提供了关键限制。随着质谱和测量技术的进步，¹⁴² Nd/ ¹⁴⁴低至 ±2 ppm（百万分之一）的 Nd 测量值、源自样品纯化不足（基质效应和/或同量异位素干扰）或非定量产量的系统偏差正变得越来越成问题。最普遍的 Nd 纯化方法之一是使用带有 α-HIBA（2-甲基乳酸）试剂的阳离子交换柱色谱法。尽管它很受欢迎，但存在与 α-HIBA 方法的纯化水平和产量有关的限制。在这里，我们提出了一个优化的 α-HIBA 纯化方案，它解决了这些限制，并达到了常规高精度 Nd 同位素分析所需的纯度水平。该协议建立在现有的方法论和我们执行的一系列综合测试的基础上，并有效地最大限度地减少了程序空白、色谱柱通过次数、从而缩短样品处理时间，同时最大限度地提高回收率。我们预计这种优化的协议将使 α-HIBA 柱层析方法的老用户和新用户都受益。

更新日期：2021-07-30

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