Natural killer (NK) cells participate in cancer immunosurveillance and cancer immunotherapy. Live cell imaging of cancer cells targeted by NK cells, published today in BMC Biology by Zhu et al., reveals a remarkable diversity of programmed cell death pathways induced in individual cells. Pathway choice depends on the state of the target cell actin cytoskeleton and a novel death pathway, granzyme-induced necroptosis, could be of broad importance in cancer immunotherapy.

中文翻译：

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自然杀死癌细胞的方法有很多


自然杀伤（NK）细胞参与癌症免疫监视和癌症免疫治疗。 Zhu 等人今天在 BMC Biology 上发表了 NK 细胞靶向癌细胞的活细胞成像，揭示了单个细胞中诱导的程序性细胞死亡途径的显着多样性。途径的选择取决于靶细胞肌动蛋白细胞骨架的状态，而一种新的死亡途径，即颗粒酶诱导的坏死性凋亡，可能在癌症免疫治疗中具有广泛的重要性。