Neglected but not negligible aspects of antidepressants and their availability in bipolar depression,Brain and Behavior

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Neglected but not negligible aspects of antidepressants and their availability in bipolar depression
Brain and Behavior ( IF 2.6 ) Pub Date : 2021-07-29 , DOI: 10.1002/brb3.2308
Takeshi Terao ₁

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Although many antidepressants are available, they are not always used appropriately. For appropriate use of antidepressants, the old concept of a linear dose–response relationship, in which the dose is linearly increased to achieve a sufficient antidepressant effect, should be reconsidered. Furthermore, there is ongoing debate on the safe and appropriate use of antidepressants in patients with bipolar depression. Antidepressants may be used under certain conditions in patients with bipolar depression. These neglected—but not negligible—aspects of antidepressants have been discussed herein.

中文翻译：

抗抑郁药的被忽视但不可忽视的方面及其在双相抑郁症中的可用性

尽管有许多抗抑郁药可用，但它们的使用并不总是适当的。为了适当使用抗抑郁药，应重新考虑线性剂量反应关系的旧概念，即线性增加剂量以达到足够的抗抑郁作用。此外，关于双相抑郁患者安全和适当使用抗抑郁药的争论仍在继续。在某些情况下，双相抑郁症患者可以使用抗抑郁药。本文讨论了抗抑郁药的这些被忽视但不可忽视的方面。

更新日期：2021-09-03

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