Homologous Recombination (HR) is a critical DNA repair mechanism for a range of genome lesions. HR is responsible for mending DNA double strand breaks (DSBs) using intact template DNA. In addition, many HR proteins help cope with DNA lesions generated from DNA replication and telomere deficiency. The functions of HR proteins are often regulated by protein modifications that can quickly and reversibly adjust substrate proteins’ attributes. Sumoylation is one of the prevalent modifications that affects all steps of the HR processes and exerts diverse regulation on substrates. This review aims to summarize the most recent advances in our understanding of SUMO-based HR regulation and highlight some key questions that remain to be elucidated.

同源重组 (HR) 是一系列基因组损伤的关键 DNA 修复机制。HR 负责使用完整的模板 DNA 修复 DNA 双链断裂 (DSB)。此外，许多 HR 蛋白有助于应对 DNA 复制和端粒缺陷产生的 DNA 损伤。HR 蛋白的功能通常受到蛋白质修饰的调节，这些修饰可以快速、可逆地调整底物蛋白的属性。苏酰化是影响 HR 过程所有步骤并对底物施加多种调节的普遍修饰之一。本综述旨在总结我们对基于 SUMO 的人力资源监管的理解的最新进展，并强调一些仍有待阐明的关键问题。