Type B aortic dissection is a major aortic catastrophe that can be acutely complicated by rapid expansion, rupture, and malperfusion syndromes. The separation of the intima from aortic walls will form a second blood-filled lumen defined as “false lumen (FL)”, where the thrombus is more likely to form due to the local stasis hemodynamic conditions. Complete thrombosis of FL is associated with a beneficial outcome while patency and partial thrombosis will lead to later complications. However, the thrombosis mechanism is still unclear and little is known about the impact of chemical species transported by blood flow on this process. The proteins involved in the coagulation cascade (CC) may play an important role in the process of thrombosis, especially in the activation and stabilization of platelets. Based on this hypothesis, a reduced-order fluid-chemical model was established to simulate CC in an aortic dissection phantom with two tears. A high level of fibrin is continuously observed at the top of the FL and some time-varying areas between two tears, indicating a high likelihood of thrombus formation there. This finding is consistent with the clinical observation. The time evolution of coagulation factors is greatly affected by local hemodynamics, especially in the high disturbance zone where the evolution has characteristics of periodic changes consistent with the flow field. The ability of the proposed model to reproduce the CC response provides a potential application to integrate with a model that can simulate platelet activities, forming a biochemical-based model which would help unveil the mechanisms of thrombosis in FL and the clinical decision of appropriate treatment.

B 型主动脉夹层是一种主要的主动脉灾难，可因快速扩张、破裂和灌注不良综合征而严重并发。内膜与主动脉壁的分离将形成第二个充满血液的腔，定义为“假腔 (FL)”，由于局部停滞的血流动力学条件，血栓更容易形成。FL 的完全血栓形成与有益结果相关，而通畅和部分血栓形成将导致后期并发症。然而，血栓形成机制仍不清楚，关于血流运输的化学物质对这一过程的影响知之甚少。参与凝血级联 (CC) 的蛋白质可能在血栓形成过程中发挥重要作用，尤其是在血小板的活化和稳定中。基于这个假设，建立了一个降阶流体化学模型来模拟主动脉夹层模型中带有两个撕裂的 CC。在 FL 的顶部和两次撕裂之间的一些随时间变化的区域连续观察到高水平的纤维蛋白，表明那里形成血栓的可能性很高。这一发现与临床观察一致。凝血因子的时间演化受局部血流动力学影响较大，尤其是在高扰动区，其演化具有与流场一致的周期性变化特征。所提出的模型再现 CC 响应的能力提供了与可以模拟血小板活动的模型集成的潜在应用，