Aims

The objective of this study is to explore the relationship between serum 25‐hydroxyvitamin-D(25-(OH)₂D₃) level and sweat function in patients with type 2 diabetes mellitus (T2DM).

Methods

A cross-sectional study of 1021 patients with T2DM who underwent 25-(OH)₂D₃ level detections and sweat function tests was carried out. These individuals were divided into deficient groups (n = 154 cases), insufficient groups (n = 593 cases) and sufficient groups (n = 274 cases). Spearman correlation analysis and multivariate stepwise linear regression analysis were implemented to determine the association of 25-(OH)2D3 level and sweat function.

Results

The total presence of sweating dysfunction was 38.59%. Patients with a lower level of serum 25-(OH)₂D₃ had more severe sweat secretion impairment (P < 0.05). As the decrease of serum 25-(OH)₂D₃ level, the presence of sweating dysfunction increased (P < 0.05). 25-(OH)₂D₃ level was positively correlated with sweat function parameters, age and duration of T2DM were negatively correlated with sweat function parameter (P < 0.05). Multivariate stepwise linear regression analysis explored a significant association between serum 25-(OH)₂D₃ level with sweat function (P < 0.05).

Conclusions

Serum 25-(OH)₂D₃ level was positively correlated with sweat function in patients with T2DM.

中文翻译：

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2型糖尿病患者血清25-羟基维生素D水平与汗液功能的关系

目标

本研究旨在探讨2 型糖尿病 (T2DM) 患者血清 25-羟基维生素-D(25-(OH) ₂ D _{3 ) 水平与汗液功能的关系。}

方法

_{对 1021 名接受 25-(OH) 2} D ₃水平检测和汗液功能测试的 T2DM 患者进行了横断面研究。将这些个体分为不足组（n  = 154 例）、不足组（n  = 593 例）和充足组（n  = 274 例）。实施Spearman相关分析和多元逐步线性回归分析以确定25-(OH)2D3水平与汗液功能的关联。

结果

出汗功能障碍的总存在率为38.59%。_{血清25-(OH) 2} D ₃水平较低的患者汗液分泌障碍更严重（P  < 0.05）。随着血清25-(OH) ₂ D ₃水平的降低，出汗功能障碍的存在增加( P  < 0.05)。25-(OH) ₂ D ₃水平与汗液功能参数呈正相关，T2DM的年龄和病程与汗液功能参数呈负相关（P  < 0.05）。多元逐步线性回归分析探讨了血清 25-(OH) ₂ D _{3之间的显着关联}出汗功能水平( P  < 0.05)。

结论

T2DM患者血清25-(OH) ₂ D _{3水平与汗液功能呈正相关。}