In order to provide favorable conditions for bone regeneration, a lot of biomaterials have been developed and evaluated, worldwide. Composite biomaterials have gained notoriety, as they combine desirable properties of each isolated material. Thus, in this research, bone repair capacity of three developed formulations of ceramic scaffolds were evaluated histomorphometrically, after implantation. Scaffolds were based on wollastonite (W) and β-tricalcium phosphate (β-TCP) composites in three different ratios (wt.%). Thirty Wistar rats were randomly assigned to three experimental groups: W-20 (20 W/80β-TCP wt.%), W-60 (60 W/40β-TCP wt.%), and W-80 (80 W/20β-TCP wt.%), evaluated by optical microscopy at biological tests after 15 and 45 days of implantation. Throughout the study, the histological results evidenced that the scaffolds remained at the implantation site, were biocompatible and presented osteogenic potential. The percentage of neoformed mineralized tissue was more evident in the W-20 group (51%), at 45 days. The composite of the W-80 group showed more evident biodegradation than the biomaterials of the W-20 and W-60 groups. Thus, it is concluded that the scaffold containing 20 W/80β-TCP (wt.%) promoted more evident bone formation, but all composites evaluated in this study showed notorious bioactivity and promising characteristics for clinical application.

为了为骨再生提供有利条件，世界范围内已经开发和评估了许多生物材料。复合生物材料已经臭名昭著，因为它们结合了每种分离材料的理想特性。因此，在这项研究中，三种开发的陶瓷支架配方的骨修复能力在植入后进行了组织形态学评估。支架基于硅灰石 (W) 和β-磷酸三钙 ( β -TCP) 复合材料，具有三种不同的比例 (wt.%)。30只Wistar大鼠被随机分配到三个实验组：W-20 (20 W/80 β -TCP wt.%)、W-60 (60 W/40 β -TCP wt.%) 和 W-80 (80 W /20 β-TCP wt.%），在植入 15 天和 45 天后通过光学显微镜在生物测试中进行评估。在整个研究过程中，组织学结果证明支架保留在植入部位，具有生物相容性并具有成骨潜力。在 45 天时，W-20 组 (51%) 中新生矿化组织的百分比更为明显。W-80组的复合材料比W-20和W-60组的生物材料表现出更明显的生物降解性。因此，得出的结论是，含有 20 W/80 β -TCP (wt.%) 的支架促进了更明显的骨形成，但本研究中评估的所有复合材料都显示出臭名昭著的生物活性和临床应用前景。