Bisphenol A (BPA) is a widely used chemical that is found in wastewaters and surface water due to its ineffective removal by conventional water treatment processes. BPA being an endocrine disruptor, regulations and different technologies have been proposed for its treatment. In this work, the use of natural solvents such as terpenoids and eutectic solvents is presented, envisioning a BPA extraction from aqueous solutions based on the hydrophobicity of these sustainable solvents. First, an initial screening of 43 solvents was performed by molecular simulation using the COSMO-RS method. BPA extraction from aqueous solutions was experimentally evaluated with initial BPA concentrations of 5 to 100 mg/L, and several solvent-to-feed ratios at 303.2 K. Extraction yields >99% were obtained with eucalyptol, geraniol, and (menthol + camphor) eutectic solvent outperforming conventional solvents. Eucalyptol, geraniol, and (menthol + camphor) have been used in a scaling-up evaluation and reuse in 6 consecutive cycles observing yields in all stages above 98.5% at solvent-to-feed ratios ranging 0.01-0.05. Besides, the solvents were regenerated using back-extraction with NaOH, providing yields above 99.5%. The regenerated solvents showed similar yields to those obtained with fresh solvent, and their chemical stability was checked through FTIR analysis. BPA was recovered by precipitation from the aqueous back-extraction solution, showing by FTIR that no degradation occurs during the extraction, back-extraction, and precipitation processes. For the first time, the complete cycle of extraction with solvent reuse, back-extraction, and precipitation of BPA using eutectic solvents and terpenoids has been studied.

双酚 A (BPA) 是一种广泛使用的化学品，由于传统水处理工艺无法有效去除双酚 A，因此在废水和地表水中发现了它。BPA 是一种内分泌干扰物，已提出对其治疗的法规和不同技术。在这项工作中，提出了使用天然溶剂，如萜类化合物和低共熔溶剂，设想基于这些可持续溶剂的疏水性从水溶液中提取 BPA。首先，使用 COSMO-RS 方法通过分子模拟对 43 种溶剂进行了初步筛选。从水溶液中提取 BPA 通过实验评估，初始 BPA 浓度为 5 至 100  mg/L，几种溶剂与进料比为 303.2 K. 桉树脑、香叶醇和（薄荷醇 + 樟脑）共晶溶剂的萃取率 > 99%，优于传统溶剂。桉油精、香叶醇和（薄荷醇 + 樟脑）已用于放大评估，并在连续 6 个循环中重复使用，观察到在溶剂与进料比范围为 0.01-0.05 时所有阶段的产率均高于 98.5%。此外，溶剂使用NaOH反萃取再生，产率超过99.5%。再生溶剂的收率与使用新鲜溶剂获得的收率相似，并且通过 FTIR 分析检查了它们的化学稳定性。BPA 通过从反萃取水溶液中沉淀回收，FTIR 表明在萃取、反萃取和沉淀过程中没有发生降解。首次，