In this paper, a new and efficient method was developed to prepare 2-aminothiophene derivatives through improved Gewald reaction. Thirty-one final products were synthesized under microwave radiation for 30 min with 57%-95% isolated yield. All the products were could be used as building blocks in drug discovery.

中文翻译：

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通过改进的 Gewald 反应在微波辅助下合成 2-氨基噻吩衍生物

在本文中，一种新的和有效的方法被开发通过改进gewald反应，以制备2-氨基噻吩衍生物。在微波辐射下 30 分钟合成了 31 种最终产物，分离产率为 57%-95%。所有产品都可以用作药物发现的构建模块。