Background: Previous studies have shown inconsistent results for associations between vitamin D and risk of stroke. We gathered the existing published articles and conducted this meta-analysis with the aim to explore the association between vitamin D and risk of stroke. Methods: We searched for articles exploring the association between vitamin D and risk of stroke and published before April 2021 in the following databases: PubMed, Web of Science, MEDLINE, EMBASE, and Google Scholar. All statistical analyses were made using STATA 12.0 software. Q test and I² were applied to examine heterogeneities between studies. Results: For the association between serum levels of 25(OH) vitamin D and risks of stroke, the present analysis included 20 cohort studies (including 213,276 participants) and a case-control analysis (including 13,642 participants). Additionally, the analysis included 15 studies (including 41,146 participants given vitamin D supplementation and 41,163 participants given placebo) to evaluate the influence of vitamin D supplementation on risk of stroke. Higher circulating levels of 25(OH) vitamin D were associated with a reduced risk of stroke (odds ratio/relative risk = 0.78, 95% confidence interval [CI]: 0.70–0.86, I² = 41.5%, p = 0.025). However, the present analysis showed that vitamin D supplementation did not influence the risk of stroke (hazard ratio = 1.05, 95% CI: 0.96–1.14, I² = 2.3%, p = 0.425). Conclusions: Our analysis indicated that lower circulating level of vitamin D was associated with an elevated risk of stroke, but extra supplement of vitamin D failed to show benefit in decreasing the risk of stroke. Further research and study are also needed to show the role of vitamin D in relation to stroke.
Eur Neurol

中文翻译：

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维生素 D 与中风风险之间的关联：符合 PRISMA 标准的系统评价和荟萃分析

背景：以前的研究表明，维生素 D 与中风风险之间的关联结果不一致。我们收集了现有发表的文章并进行了这项荟萃分析，旨在探索维生素 D 与中风风险之间的关联。方法：我们搜索了探索维生素 D 与中风风险之间关系的文章，并于 2021 年 4 月之前在以下数据库中发表：PubMed、Web of Science、MEDLINE、EMBASE 和 Google Scholar。所有统计分析均使用 STATA 12.0 软件进行。应用Q 检验和I ²来检查研究之间的异质性。结果：对于血清 25(OH) 维生素 D 水平与中风风险之间的关联，目前的分析包括 20 项队列研究（包括 213,276 名参与者）和一项病例对照分析（包括 13,642 名参与者）。此外，该分析包括 15 项研究（包括 41,146 名服用维生素 D 补充剂的参与者和 41,163 名服用安慰剂的参与者），以评估维生素 D 补充剂对中风风险的影响。较高的 25(OH) 维生素 D 循环水平与卒中风险降低相关（优势比/相对风险 = 0.78，95% 置信区间 [CI]：0.70-0.86，I ² = 41.5%，p= 0.025)。然而，目前的分析表明，补充维生素 D 不会影响中风的风险（风险比 = 1.05，95% CI：0.96–1.14，I ² = 2.3%，p = 0.425）。结论：我们的分析表明，较低的维生素 D 循环水平与卒中风险升高相关，但额外补充维生素 D 未能显示出降低卒中风险的益处。还需要进一步的研究和研究来证明维生素 D 与中风有关的作用。
欧洲神经元