Background

Depression often onsets in adolescence and is associated with recurrence in adulthood. There is a need to identify and monitor depression symptoms across adolescence and into young adulthood. The short Mood and Feelings Questionnaire (sMFQ) is commonly used to measure depression symptoms in adolescence but has not been validated in young adulthood. This study aimed to (1) examine whether the sMFQ is valid in young adulthood, and (2) identify cut-points best capturing DSM-5 depression diagnosis at age 25

Methods

The sample included participants in the Avon Longitudinal Study of Parents and Children (ALSPAC) at age 25 (n=4098). Receiver Operating Characteristic analyses examined how well the self-rated sMFQ discriminates between cases and non-cases of DSM-5 Major Depressive Disorder (MDD) classified using the self-rated Development and Well Being Assessment. Sensitivity and specificity values were used to identify cut-points on the sMFQ

Results

The sMFQ had high accuracy for discriminating MDD cases from non-cases at age 25. The commonly used cut-point in adolescence (≥12) performed well at this age, best balancing sensitivity and specificity. However, a lower cut-point (≥10) may be appropriate when favouring sensitivity over specificity e.g., in context of screening. Sensitivity analyses suggested similar results for males and females

Limitations

ALSPAC is a longitudinal population cohort that suffers from non-random attrition

Conclusions

The sMFQ is a valid measure of depression in young adults in the general population. It can be used to screen for and monitor depression across adolescence and early adulthood.

中文翻译：

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青年期短期情绪和感觉问卷的验证

背景

抑郁症通常在青春期发作，并与成年期复发有关。有必要识别和监测整个青春期和成年后的抑郁症状。简短的情绪和感觉问卷 (sMFQ) 通常用于测量青春期的抑郁症状，但尚未在青年期得到验证。本研究旨在 (1) 检查 sMFQ 在青年期是否有效，以及 (2) 确定在 25 岁时最能捕捉 DSM-5 抑郁症诊断的切点

方法

样本包括雅芳父母和儿童纵向研究 (ALSPAC) 的 25 岁参与者 (n=4098)。接受者操作特征分析检查了自评 sMFQ 在使用自评发展和幸福评估分类的 DSM-5 重度抑郁症 (MDD) 病例和非病例之间的区别。灵敏度和特异性值用于识别 sMFQ 上的切点

结果

sMFQ 在区分 25 岁时的 MDD 病例和非病例方面具有很高的准确性。青春期常用的切点（≥12）在这个年龄表现良好，最佳平衡了敏感性和特异性。然而，当优先考虑敏感性而不是特异性时，较低的临界点 (≥10) 可能是合适的，例如，在筛选的情况下。敏感性分析表明男性和女性的结果相似

限制

ALSPAC 是一个纵向人口队列，遭受非随机减员

结论

sMFQ 是衡量普通人群中年轻人抑郁症的有效指标。它可用于筛查和监测青春期和成年早期的抑郁症。