Abstract

This work reports on the microstructure and antibacterial properties of electrospun carboxy methyl chitosan/poly(ethylene oxide) (CMCH/PEO) and carboxy methyl chitosan/poly(vinyl alcohol) (CMCH/PVA) nanofibers. The highest share of CMCH in CMCH/PEO and CMCH/PVA in beadless nanofibers was about 50% and 28%, respectively. Higher proportions of CMCH led to unacceptable nanofibers. Depending on the share of the components, an average diameter in the range of 83–209 nm and 218–458 nm was obtained for CMCH/PEO and CMCH/PVA nanofibers, respectively. The average diameter of the nanofibers increased with higher viscosities and decreased with higher electrical conductivity of the electrospinning solutions. FTIR analysis showed interactions between CMCH and PEO or PVA in the hybrid nanofibers. XRD analysis showed dispersed crystallites in a non-crystalline matrix for both CMCH/PEO and CMCH/PVA nanofibers. Both hybrid nanofibers showed a high antibacterial activity against Staphylococcus aureus.

摘要

这项工作报告了电纺羧甲基壳聚糖/聚（环氧乙烷）（CMCH/PEO）和羧甲基壳聚糖/聚（乙烯醇）（CMCH/PVA）纳米纤维的微观结构和抗菌性能。CMCH/PEO 和 CMCH/PVA 在无珠纳米纤维中的最高份额分别约为 50% 和 28%。较高比例的 CMCH 导致不可接受的纳米纤维。根据组分的份额，CMCH/PEO 和 CMCH/PVA 纳米纤维的平均直径分别为 83-209 nm 和 218-458 nm。纳米纤维的平均直径随着静电纺丝溶液的较高粘度而增加，而随着静电纺丝溶液的较高电导率而减小。FTIR 分析显示混合纳米纤维中 CMCH 和 PEO 或 PVA 之间的相互作用。XRD 分析显示 CMCH/PEO 和 CMCH/PVA 纳米纤维在非结晶基质中分散有微晶。两种混合纳米纤维均显示出高抗菌活性金黄色葡萄球菌。