Organophotoredox-Catalyzed Decarboxylative N-Alkylation of Sulfonamides,ChemCatChem

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Organophotoredox-Catalyzed Decarboxylative N-Alkylation of Sulfonamides
ChemCatChem ( IF 3.8 ) Pub Date : 2021-07-29 , DOI: 10.1002/cctc.202100803
Masanari Nakagawa ₁ , Kazunori Nagao ₁ , Zenichi Ikeda ₂ , Matthew Reynolds ₂ , Ignacio Ibáñez ₂ , Junsi Wang ₂ , Norihito Tokunaga ₂ , Yusuke Sasaki ₂ , Hirohisa Ohmiya _{1,

3}

Affiliation

We developed an organophotoredox-catalyzed reaction for N-alkylation of sulfonamides with aliphatic carboxylic acid-derived redox active esters as alkylating reagents. Under mild and transition metal-free conditions, a series of functionalized N-alkylated sulfonamides were prepared. This protocol also enabled the functionalization of pharmaceutical drugs bearing a sulfonamide or carboxylic acid moiety. This radical-mediated process allowed the assembly of three components including sulfonamides, redox active esters, and alkenes to yield complex sulfonamides in a one-pot manner.

中文翻译：

有机光氧化还原催化的磺酰胺脱羧 N-烷基化

我们开发了一种有机光氧化还原催化反应，以脂肪族羧酸衍生的氧化还原活性酯作为烷基化试剂，用于磺酰胺的 N-烷基化。在温和且无过渡金属的条件下，制备了一系列功能化的 N-烷基化磺酰胺。该协议还实现了带有磺胺或羧酸部分的药物的功能化。这种自由基介导的过程允许三种成分的组装，包括磺酰胺、氧化还原活性酯和烯烃，以一锅法产生复杂的磺酰胺。

更新日期：2021-09-17

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