ABSTRACT

Copper has been shown to plays an important role in immune functions. The aim of the study was to determine the effect of inorganic and organic forms of copper on the concentrations of cytokines, acute phase proteins and prostanoids in the peripheral blood and liver of poultry. The concentration of copper in serum and tissues was also determined. A total of 900 1-day-old Ross 308 male chickens were used. The rearing period was 42 days. The material for analysis comprised samples of peripheral blood, liver, intestine and muscle of experimental chickens. The obtained results indicate that the supplementation of broilers feed with copper chelates promotes secretion of pro and anti-inflammatory cytokines. Increased synthesis of the immunoregulatory serum amyloid A (SAA) and alpha-1-acid glycoprotein (α-AGP) and prostanoids following the administration of copper-glycine chelates in the diet indicates the stimulatory effect of copper on cellular and humoral immune mechanisms.

摘要

铜已被证明在免疫功能中起着重要作用。该研究的目的是确定无机和有机形式的铜对家禽外周血和肝脏中细胞因子、急性期蛋白和前列腺素浓度的影响。还测定了血清和组织中铜的浓度。总共使用了900只1日龄Ross 308雄性鸡。饲养期为42天。分析材料包括实验鸡的外周血、肝脏、肠道和肌肉样品。所得结果表明，在肉鸡饲料中添加铜螯合物可促进促炎和抗炎细胞因子的分泌。