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Fitness dependence preserves selection for recombination across diverse mixed mating strategies
Journal of Theoretical Biology ( IF 1.9 ) Pub Date : 2021-07-29 , DOI: 10.1016/j.jtbi.2021.110849
Sviatoslav Rybnikov 1 , Daniel B Weissman 2 , Sariel Hübner 3 , Abraham B Korol 1
Affiliation  

Meiotic recombination and the factors affecting its rate and fate in nature have inspired many studies in theoretical evolutionary biology. Classical theoretical models have inferred that recombination can be favored under a rather restricted parameter range. Thus, the ubiquity of recombination in nature remains an open question. However, these models assumed constant recombination with an equal rate across all individuals within the population, whereas empirical evidence suggests that recombination may display certain sensitivity to ecological stressors and/or genotype fitness. Models assuming condition-dependent recombination show that such a strategy can often be favored over constant recombination. Moreover, in our recent model with panmictic populations subjected to purifying selection, fitness-dependent recombination was quite often favored even when any constant recombination was rejected. By using numerical modeling, we test whether such a ‘recombination-rescuing potential’ of fitness dependence holds also beyond panmixia, given the recognized effect of mating strategy on the evolution of recombination. We show that deviations from panmixia generally increase the recombination-rescuing potential of fitness dependence, with the strongest effect under intermediate selfing or high clonality. We find that under partial clonality, the evolutionary advantage of fitness-dependent recombination is determined mostly by selection against heterozygotes and additive-by-additive epistasis, while under partial selfing, additive-by-dominance epistasis is also a driver.



中文翻译:

适应度依赖性保留了跨不同混合交配策略的重组选择

减数分裂重组及其在自然界中影响其速率和命运的因素激发了理论进化生物学的许多研究。经典理论模型推断,在相当有限的参数范围内可以有利于重组。因此,自然界中重组的普遍性仍然是一个悬而未决的问题。然而,这些模型假设种群内所有个体的重组率相同,而经验证据表明重组可能对生态压力源和/或基因型适应性表现出一定的敏感性。假设条件依赖重组的模型表明,这种策略通常比持续重组更受欢迎。此外,在我们最近的模型中,恐慌种群受到净化选择,即使在拒绝任何不断的重组时,适应性依赖的重组也经常受到青睐。通过使用数值建模,考虑到交配策略对重组进化的公认影响,我们测试了这种适应性依赖的“重组拯救潜力”是否也适用于泛混合。我们表明,与 panmixia 的偏差通常会增加适应性依赖的重组拯救潜力,在中间自交或高克隆性下效果最强。我们发现,在部分克隆性下,适应性依赖重组的进化优势主要取决于对杂合子的选择和逐加性上位性,而在部分自交下,逐优势性上位性也是一个驱动因素。通过使用数值建模,考虑到交配策略对重组进化的公认影响,我们测试了这种适应性依赖的“重组拯救潜力”是否也适用于泛混合。我们表明,与 panmixia 的偏差通常会增加适应性依赖的重组拯救潜力,在中间自交或高克隆性下效果最强。我们发现,在部分克隆性下,适应性依赖重组的进化优势主要取决于对杂合子的选择和逐加性上位性,而在部分自交下,逐优势性上位性也是一个驱动因素。通过使用数值建模,考虑到交配策略对重组进化的公认影响,我们测试了这种适应性依赖的“重组拯救潜力”是否也适用于泛混合。我们表明,与 panmixia 的偏差通常会增加适应性依赖的重组拯救潜力,在中间自交或高克隆性下效果最强。我们发现,在部分克隆性下,适应性依赖重组的进化优势主要取决于对杂合子的选择和逐加性上位性,而在部分自交下,逐优势性上位性也是一个驱动因素。鉴于交配策略对重组进化的公认影响。我们表明,与 panmixia 的偏差通常会增加适应性依赖的重组拯救潜力,在中间自交或高克隆性下效果最强。我们发现,在部分克隆性下,适应性依赖重组的进化优势主要取决于对杂合子的选择和逐加性上位性,而在部分自交下,逐优势性上位性也是一个驱动因素。鉴于交配策略对重组进化的公认影响。我们表明,与 panmixia 的偏差通常会增加适应性依赖的重组拯救潜力,在中间自交或高克隆性下效果最强。我们发现,在部分克隆性下,适应性依赖重组的进化优势主要取决于对杂合子的选择和逐加性上位性,而在部分自交下,逐优势性上位性也是一个驱动因素。

更新日期:2021-08-05
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