The interplay of carbophilic activation and Au(I)/Au(III) catalysis: an emerging technique for 1,2-difunctionalization of C–C multiple bonds,Chemical Society Reviews

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The interplay of carbophilic activation and Au(I)/Au(III) catalysis: an emerging technique for 1,2-difunctionalization of C–C multiple bonds
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2021-07-29 , DOI: 10.1039/d0cs00700e
Vivek W Bhoyare ₁ , Akash G Tathe ₁ , Avishek Das ₁ , Chetan C Chintawar ₁ , Nitin T Patil ₁

Affiliation

Gold complexes have emerged as the catalysts of choice for various functionalization reactions of C–C multiple bonds due to their inherent carbophilic nature. In a parallel space, efforts to realize less accessible cross-coupling reactivity have led to the development of various strategies that facilitate the arduous Au(I)/Au(III) redox cycle. The interplay of the two important reactivity modes encountered in gold catalysis, namely carbophilic activation and Au(I)/Au(III) catalysis, has allowed the development of a novel mechanistic paradigm that sponsors 1,2-difunctionalization reactions of various C–C multiple bonds. Interestingly, the reactivity as well as selectivity obtained through this interplay could be complementary to that obtained by the use of various other transition metals that mainly involved the classical oxidative addition/migratory insertion pathways. The present review shall comprehensively cover all the 1,2-difunctionalization reactions of C–C multiple bonds that have been realized by the interplay of the two important reactivity modes and categorized on the basis of the method that has been employed to foster the Au(I)/Au(III) redox cycle.

中文翻译：

亲碳活化和 Au(I)/Au(III) 催化的相互作用：一种新兴的 C-C 多键 1,2-双官能化技术

由于其固有的碳亲性，金配合物已成为 C-C 多键各种功能化反应的首选催化剂。在平行空间中，实现不易接近的交叉偶联反应性的努力导致了各种策略的发展，这些策略促进了艰难的 Au( I )/Au( III ) 氧化还原循环。金催化中遇到的两种重要反应模式的相互作用，即碳亲化活化和 Au( I )/Au( III)) 催化，促进了一种新的机械范式的发展，该范式支持各种 C-C 多重键的 1,2-双官能化反应。有趣的是，通过这种相互作用获得的反应性和选择性可以与通过使用主要涉及经典氧化加成/迁移插入途径的各种其他过渡金属获得的反应性和选择性互补。本综述将全面涵盖通过两种重要反应模式的相互作用实现的 C-C 多键的所有 1,2-双官能化反应，并根据用于培育 Au( I )/Au( III ) 氧化还原循环。

更新日期：2021-07-29

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