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Lipid and metabolite correlation networks specific to clinical and biochemical covariate show differences associated with sexual dimorphism in a cohort of nonagenarians
GeroScience ( IF 5.3 ) Pub Date : 2021-07-29 , DOI: 10.1007/s11357-021-00404-3
Francesca Di Cesare 1 , Leonardo Tenori 1, 2 , Gaia Meoni 3 , Anna Maria Gori 4, 5 , Rossella Marcucci 4, 5 , Betti Giusti 4, 5 , Raffaele Molino-Lova 6 , Claudio Macchi 4, 6 , Silvia Pancani 6 , Claudio Luchinat 1, 2, 7 , Edoardo Saccenti 8
Affiliation  

This study defines and estimates the metabolite-lipidic component association networks constructed from an array of 20 metabolites and 114 lipids identified and quantified via NMR spectroscopy in the serum of a cohort of 355 Italian nonagenarians and ultra-nonagenarian. Metabolite-lipid association networks were built for men and women and related to an array of 101 clinical and biochemical parameters, including the presence of diseases, bio-humoral parameters, familiarity diseases, drugs treatments, and risk factors. Different connectivity patterns were observed in lipids, branched chains amino acids, alanine, and ketone bodies, suggesting their association with the sex-related and sex-clinical condition-related intrinsic metabolic changes. Furthermore, our results demonstrate, using a holistic system biology approach, that the characterization of metabolic structures and their dynamic inter-connections is a promising tool to shed light on the dimorphic pathophysiological mechanisms of aging at the molecular level.



中文翻译:

特定于临床和生化协变量的脂质和代谢物相关网络显示出与非老年人群中性二态性相关的差异

本研究定义和估计代谢物-脂质成分关联网络,该网络由 20 种代谢物和 114 种脂质组成,通过核磁共振波谱在 355 名意大利九岁老人和超九岁老人的血清中鉴定和量化。为男性和女性建立了代谢物-脂质关联网络,并与一系列 101 个临床和生化参数相关,包括疾病的存在、生物体液参数、熟悉的疾病、药物治疗和风险因素。在脂质、支链氨基酸、丙氨酸和酮体中观察到不同的连接模式,表明它们与性别相关和性别临床状况相关的内在代谢变化有关。此外,我们的结果表明,使用整体系统生物学方法,

更新日期:2021-07-29
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