Diagnostic investigation on pachychoroid spectrum disease (PSD) has been growing along with the rapid advancement of imaging technology. In optical coherence tomography (OCT)-based studies, choroidal thickness profile, luminal and stromal choroidal ratio, and abnormalities in the neurosensory retina have demonstrated various patterns in different clinical entities related to PSD. The emerging role of OCT angiography ()CTA) has been expanded to involve the quantitative analysis of the OCTA parameters in different clinical entities of PSD and to evaluate the choriocapillaris signal void and vessel density as indicators of choriocapillaris ischemia. OCTA has broadened our knowledge in characterization and assessment of both active and quiescent choroidal neovascularization and its association with treatment response. Recent studies using indocyanine green angiography have focused on the evaluation of choroidal vascular hyperpermeability and its relationship with other pachychoroid related features. Ultra-widefield indocyanine green angiography enables observation and characterization of peripheral choroidal pathologies and their associations with macular abnormalities. Multicolor imaging is an emerging modality with the capability to demonstrate early abnormalities in PSD. We summarize all investigations reflecting the new insights into the application of multimodal imaging for PSD and focus on novel findings observed in different clinical entities with each imaging modality.

随着影像学技术的飞速发展，厚脉络膜疾病（PSD）的诊断研究也在不断发展。在基于光学相干断层扫描 (OCT) 的研究中，脉络膜厚度分布、腔和基质脉络膜比率以及神经感觉视网膜异常在与 PSD 相关的不同临床实体中表现出不同的模式。OCT 血管造影 () CTA) 的新兴作用已扩大到涉及 PSD 不同临床实体中 OCTA 参数的定量分析，并评估脉络膜毛细血管信号空洞和血管密度作为脉络膜毛细血管缺血的指标。OCTA 拓宽了我们在表征和评估活动和静止脉络膜新生血管及其与治疗反应的关系方面的知识。最近使用吲哚菁绿血管造影的研究集中在评估脉络膜血管高渗透性及其与其他厚脉络膜相关特征的关系。超宽视野吲哚菁绿血管造影能够观察和表征外周脉络膜病变及其与黄斑异常的关联。多色成像是一种新兴的方式，能够证明 PSD 的早期异常。我们总结了反映多模态成像在 PSD 中应用的新见解的所有研究，并重点关注在不同临床实体中使用每种成像模态观察到的新发现。超宽视野吲哚菁绿血管造影能够观察和表征外周脉络膜病变及其与黄斑异常的关联。多色成像是一种新兴的方式，能够证明 PSD 的早期异常。我们总结了反映多模态成像在 PSD 中应用的新见解的所有研究，并重点关注在不同临床实体中使用每种成像模态观察到的新发现。超宽视野吲哚菁绿血管造影能够观察和表征外周脉络膜病变及其与黄斑异常的关联。多色成像是一种新兴的方式，能够证明 PSD 的早期异常。我们总结了反映多模态成像在 PSD 中应用的新见解的所有研究，并重点关注在不同临床实体中使用每种成像模态观察到的新发现。