Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment,Immunology

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Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment
Immunology ( IF 4.9 ) Pub Date : 2021-07-29 , DOI: 10.1111/imm.13397
Xiuxiu Yang _{1,

2,

3} , Yaxin Guo _{3,

4,

5} , Chen Chen _{3,

6} , Bo Shao _{1,

3} , Luyang Zhao _{3,

4,

5} , Quanbo Zhou ₁ , Jinbo Liu ₁ , Guixian Wang ₁ , Weitang Yuan ₁ , Zhenqiang Sun _{1,

3}

Affiliation

In recent years, an increasing number of studies have reported that intestinal microbiota have an important effect on tumour immunity by affecting the tumour microenvironment (TME). The intestinal microbiota are closely associated with various immune cells, such as T lymphocytes, natural killer cells (NK cells) and macrophages. Some bacteria, such as Akkermansia muciniphila (A. muciniphila) and Lactobacillus reuteri (L. reuteri), have been shown to improve the effect of tumour immunity. Furthermore, microbial imbalance, such as the increased abundance of Fusobacterium nucleatum (F. nucleatum) and Helicobacter hepaticus (H. hepaticus), generally causes tumour formation and progression. In addition, some microbiota also play important roles in tumour immunotherapy, especially PD-L1-related therapies. Therefore, what is the relationship between these processes and how do they affect each other? In this review, we summarize the interactions and corresponding mechanisms among the intestinal microbiota, immune system and TME to facilitate the research and development of new targeted drugs and provide new approaches to tumour therapy.

中文翻译：

肿瘤微环境中肠道菌群与肿瘤免疫的相互作用

近年来，越来越多的研究报道肠道菌群通过影响肿瘤微环境（TME）对肿瘤免疫产生重要影响。肠道菌群与各种免疫细胞密切相关，如T淋巴细胞、自然杀伤细胞（NK细胞）和巨噬细胞。一些细菌，如嗜粘蛋白阿克曼氏菌(A. muciniphila)和罗伊氏乳杆菌(L.reuteri ) ，已被证明具有提高肿瘤免疫的效果。此外，微生物失衡，例如具核梭杆菌(F.nucleatum )和肝螺杆菌(H.hepaticus )丰度的增加，通常会导致肿瘤形成和进展。此外，一些微生物群在肿瘤免疫治疗，尤其是PD-L1相关治疗中也发挥着重要作用。那么，这些过程之间有什么关系，又是如何相互影响的呢？本文综述了肠道菌群、免疫系统和TME之间的相互作用及相应机制，以促进新靶向药物的研发，为肿瘤治疗提供新途径。

更新日期：2021-07-29

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