Extending the structural hierarchy and complexity through small-molecular self-assembly is a powerful way to obtain large discrete, functional molecular architecture. A hydrogen-bonded supramolecular organic framework (H_SOF) with nanometer-size pores is constructed in a solid state with simple guanosine-monomer self-assembly. To extend the hierarchy of the G-quartet self-assembly to a higher order than that of the traditional G-quadruplex, H-bond acceptors on the C-8 position of guanosine are introduced to establish inter-quadruplex linkage via H bonding to N(2)-H_B from the neighboring G-quartet. After screening different C-8 substitution groups and various synthesis conditions, H_SOF-G1a’ is obtained by solvent evaporation under diluted condition. Single-crystal X-ray structure reveals that cubic repeating units formed by G₈ are the supermolecule secondary building block (SBU) with large pores (d = 34 Å). To our knowledge, this is the first G-quartet self-assembly with an organized structure beyond cylindrical G-quadruplexes.

通过小分子自组装扩展结构层次和复杂性是获得大型离散功能分子结构的有效方法。具有纳米尺寸孔的氢键超分子有机骨架（H _S OF）以固态构建，具有简单的鸟苷单体自组装。为了将 G-四重体自组装的层次扩展到比传统 G-四链体更高的层次，在鸟苷的 C-8 位上引入 H 键受体，通过 H 键与 N 建立四链体间连接(2)-H _B来自相邻的 G-四重奏。经过筛选不同的C-8取代基团和各种合成条件，H _SOF-G1a'是在稀释条件下通过溶剂蒸发获得的。单晶 X 射线结构表明由 G ₈形成的立方重复单元是具有大孔 (d = 34 Å) 的超分子二级结构单元 (SBU)。据我们所知，这是第一个具有超越圆柱形 G-四链体的有组织结构的 G-四重奏自组装。